Genetic regulation of immunoglobulin E level in different pathological states: integration of mouse and human genetics

Abstract

Immunoglobulin E (IgE) first evolved in mammals. It plays an important role in defence against helminths and parasitic infection and in pathological states including allergic reactions, anti-tumour defence and autoimmune diseases. Elucidation of genetic control of IgE level could help us to understand regulation of the humoral immune response in health and disease, the etiology and pathogenesis of many human diseases, and to facilitate discovery of more effective methods for their prevention and cure. Herein we summarise progress in the genetics of regulation of IgE level in human diseases and show that integration of different approaches and use of animal models have synergistic effects in gaining new knowledge about both protective and pathological roles of this important antibody.

Keywords: complex diseases; genetic influence; human; hypothesis-driven approach; hypothesis-independent manner; immunoglobulin E; mouse; multiple interacting genes; mutation in a single gene; serum level.