Diabetes, peripheral neuropathy, and lower-extremity function

J Diabetes Complications. Jan-Feb 2014;28(1):91-5. doi: 10.1016/j.jdiacomp.2013.08.007. Epub 2013 Oct 11.


Objective: Diabetes among older adults causes many complications, including decreased lower-extremity function and physical disability. Diabetes can cause peripheral nerve dysfunction, which might be one pathway through which diabetes leads to decreased physical function. The study aims were to determine the following: (1) whether diabetes and impaired fasting glucose are associated with objective measures of physical function in older adults, (2) which peripheral nerve function (PNF) tests are associated with diabetes, and (3) whether PNF mediates the diabetes-physical function relationship.

Research design and methods: This study included 983 participants, age 65 years and older from the InCHIANTI study. Diabetes was diagnosed by clinical guidelines. Physical performance was assessed using the Short Physical Performance Battery (SPPB), scored from 0 to 12 (higher values, better physical function) and usual walking speed (m/s). PNF was assessed via standard surface electroneurographic study of right peroneal nerve conduction velocity, vibration and touch sensitivity. Clinical cutpoints of PNF tests were used to create a neuropathy score from 0 to 5 (higher values, greater neuropathy). Multiple linear regression models were used to test associations.

Results and conclusion: One hundred twenty-six (12.8%) participants had diabetes. Adjusting for age, sex, education, and other confounders, diabetic participants had decreased SPPB (β=-0.99; p<0.01), decreased walking speed (β=-0.1m/s; p<0.01), decreased nerve conduction velocity (β=-1.7m/s; p<0.01), and increased neuropathy (β=0.25; p<0.01) compared to non-diabetic participants. Adjusting for nerve conduction velocity and neuropathy score decreased the effect of diabetes on SPPB by 20%, suggesting partial mediation through decreased PNF.

Keywords: Geriatrics; Gerontology; Lower extremity function; Peripheral neuropathy.

Publication types

  • Clinical Trial
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Aging / physiology*
  • Diabetes Mellitus / epidemiology
  • Diabetes Mellitus / physiopathology*
  • Diabetic Neuropathies / epidemiology
  • Diabetic Neuropathies / physiopathology*
  • Female
  • Gait
  • Glucose Intolerance / epidemiology
  • Glucose Intolerance / physiopathology
  • Humans
  • Italy / epidemiology
  • Lower Extremity / physiopathology*
  • Male
  • Prediabetic State / epidemiology
  • Prediabetic State / physiopathology
  • Psychomotor Performance