Mechanisms of MAVS regulation at the mitochondrial membrane

J Mol Biol. 2013 Dec 13;425(24):5009-19. doi: 10.1016/j.jmb.2013.10.007. Epub 2013 Oct 9.

Abstract

Mitochondria have emerged as critical platforms for antiviral innate immune signaling. This is due in large part to the mitochondrial localization of the innate immune signaling adaptor MAVS (mitochondrial antiviral signaling protein), which coordinates signals received from two independent cytosolic pathogen recognition receptors (PRRs) to induce antiviral genes. The existence of a shared adaptor for two central PRRs presents an ideal target by which the host cell can prevent cellular damage induced by uncontrolled inflammation through alteration of MAVS expression and/or signaling. In this review, we focus on the MAVS regulome and review the cellular factors that regulate MAVS by (1) protein-protein interactions, (2) alterations in mitochondrial dynamics, and/or (3) post-translational modifications.

Keywords: CARD; COX5B; ER; FAK; IRF3; MAM; MAVS; MDA5; PCBP2; PLK1; Polo-like kinase 1; RIG-I; RIG-I-like receptor; RLR; ROS; SeV; Sendai virus; TANK binding kinase 1; TBK1; VSV; caspase activation and recruitment domain; cytochrome C oxidase 5B; endoplasmic reticulum; focal adhesion kinase; innate immunity; interferon regulatory factor 3; melanoma differentiation-associated gene 5; mitochondria-associated membrane; poly(rC) binding protein 2; reactive oxygen species; retinoic acid-inducible gene-I; vRNA; vesicular stomatitis virus; viral RNA.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adaptor Proteins, Signal Transducing / genetics
  • Adaptor Proteins, Signal Transducing / immunology
  • Adaptor Proteins, Signal Transducing / metabolism*
  • Antiviral Agents / immunology
  • Antiviral Agents / metabolism
  • Gene Expression Regulation
  • Humans
  • Immunity, Innate*
  • Mitochondria / immunology
  • Mitochondria / metabolism
  • Mitochondrial Membranes / immunology
  • Mitochondrial Membranes / metabolism
  • Models, Molecular
  • Protein Interaction Maps
  • Protein Processing, Post-Translational*
  • Regulon / immunology*
  • Signal Transduction / immunology
  • Viruses / immunology*

Substances

  • Adaptor Proteins, Signal Transducing
  • Antiviral Agents
  • MAVS protein, human