Effect of propofol on anal sphincter pressure during anorectal manometry

J Pediatr Gastroenterol Nutr. 2014 Apr;58(4):495-7. doi: 10.1097/MPG.0000000000000190.

Abstract

We evaluated the effect of propofol on resting anal sphincter pressure (RP) during anorectal manometry performed under general anesthesia in 20 children with chronic constipation. After propofol bolus administration, there was a significant decrease in the RP in 95% of children from a mean of 51.5 ± 15.3 to a mean nadir of 21.7 ± 10.5 mmHg (P < 0.001). The new postpropofol RP of 47.0 ± 12.4 mmHg was significantly lower compared with prepropofol RP (P < 0.0001). Propofol should be used with caution as an anesthetic agent for anorectal manometry, given the potential for confounding RP measurements.

Trial registration: ClinicalTrials.gov NCT01793753.

Publication types

  • Clinical Trial

MeSH terms

  • Anal Canal / drug effects*
  • Anal Canal / physiopathology
  • Anesthesia, General
  • Anesthetics, Intravenous / pharmacology*
  • Child
  • Child, Preschool
  • Constipation / physiopathology
  • Female
  • Humans
  • Male
  • Manometry*
  • Pressure
  • Propofol / pharmacology*
  • Reflex / drug effects*

Substances

  • Anesthetics, Intravenous
  • Propofol

Associated data

  • ClinicalTrials.gov/NCT01793753