Spatial and temporal patterns of Krüppel gene expression in early Drosophila embryos

Nature. 1985 Sep 5-11;317(6032):40-4. doi: 10.1038/317040a0.


The Krüppel (Kr) locus is a member of the 'gap' class of segmentation genes of Drosophila melanogaster. Mutations at the Kr locus cause the deletion of contiguous segments from the embryonic body pattern. We have elucidated the spatial and temporal characteristics of Kr gene expression during early embryo development, the localization of cytoplasmic Kr+ activity and its spatial requirement for normal segmentation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Autoradiography
  • Blastoderm / physiology
  • Drosophila melanogaster / anatomy & histology
  • Drosophila melanogaster / genetics*
  • Drosophila melanogaster / growth & development
  • Embryo, Nonmammalian / physiology
  • Female
  • Genes*
  • RNA / genetics
  • Transcription, Genetic*
  • Tritium
  • Uridine Triphosphate / metabolism


  • Tritium
  • RNA
  • Uridine Triphosphate