Abstract
The SAV3339 (SdrA) protein of Streptomyces avermitilis, a member of the DeoR family of regulators, was assessed to determine its in vivo function by gene knockdown through the use of cis-encoded noncoding RNA and knockout of the sdrA gene. These analyses revealed that SdrA represents another class of Streptomyces regulator that controls morphological development and antibiotic production.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / biosynthesis*
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Gene Expression Regulation, Bacterial*
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Gene Knockdown Techniques
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Gene Knockout Techniques
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Streptomyces / cytology*
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Streptomyces / genetics
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Streptomyces / metabolism*
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Transcription Factors / genetics*
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Transcription Factors / metabolism*
Substances
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Anti-Bacterial Agents
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Transcription Factors