Apolipoprotein E: receptor binding properties

Adv Exp Med Biol. 1985;183:159-71. doi: 10.1007/978-1-4613-2459-1_13.

Abstract

The E apoprotein plays a central role in lipoprotein metabolism. It is a key protein determinant responsible for the recognition of lipoproteins by specific lipoprotein receptors. Structure-function studies are providing insights into the normal function of this apoprotein in cholesterol homeostasis and into the clinical abnormalities resulting from the occurrence of specific mutants.

MeSH terms

  • Antibodies, Monoclonal
  • Apolipoproteins E / classification
  • Apolipoproteins E / immunology
  • Apolipoproteins E / metabolism*
  • Binding Sites
  • Binding, Competitive
  • Epitopes
  • Humans
  • Hyperlipoproteinemia Type III / metabolism*
  • Isoelectric Point
  • Peptide Fragments / metabolism
  • Receptors, Cell Surface / metabolism*
  • Receptors, LDL / metabolism
  • Receptors, Lipoprotein*
  • Structure-Activity Relationship

Substances

  • Antibodies, Monoclonal
  • Apolipoproteins E
  • Epitopes
  • Peptide Fragments
  • Receptors, Cell Surface
  • Receptors, LDL
  • Receptors, Lipoprotein
  • apolipoprotein B,E receptor