Clinicopathologic features of CD5-positive nodal marginal zone lymphoma

Am J Clin Pathol. 2013 Nov;140(5):693-700. doi: 10.1309/AJCPEMVXES72DUIF.


Objectives: To describe the clinicopathologic findings of seven patients with CD5-positive nodal marginal zone lymphoma (NMZL).

Methods: We searched cases of NMZL over a 10-year interval and identified seven cases of CD5-positive NMZL. The clinical, histologic, and immunophenotypic findings of this group were reviewed, and the frequency of dissemination in this group was compared with that of 66 patients with CD5-negative NMZL.

Results: Other than CD5 expression, the histologic and immunophenotypic findings were typical of NMZL. Six (86%) of seven patients had lymphadenopathy above and below the diaphragm, and all six patients assessed had bone marrow involvement. In the CD5-negative group, 28 (42%) patients had lymphadenopathy above and below the diaphragm, and 36 (55%) had bone marrow involvement (P = .045 and P = .037, respectively). Six of seven patients were alive at last follow-up, with a median follow-up of 32 months (3-154 months).

Conclusions: CD5 expression in NMZL correlates with a higher frequency of dissemination, but patients have an indolent clinical course and excellent overall survival.

Keywords: CD5; Nodal marginal zone lymphoma.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Biomarkers, Tumor / metabolism
  • Bone Marrow / metabolism
  • Bone Marrow / pathology
  • CD5 Antigens / metabolism*
  • Female
  • Flow Cytometry
  • Humans
  • Immunophenotyping
  • Lymph Nodes / pathology*
  • Lymphatic Diseases / pathology
  • Lymphoma, B-Cell, Marginal Zone / metabolism
  • Lymphoma, B-Cell, Marginal Zone / mortality
  • Lymphoma, B-Cell, Marginal Zone / pathology*
  • Male
  • Middle Aged
  • Neoplasm Staging
  • Survival Rate
  • Texas / epidemiology
  • Young Adult


  • Biomarkers, Tumor
  • CD5 Antigens