Severe Combined Immunodeficiency (SCID) in the Mouse. Pathology, Reconstitution, Neoplasms

Am J Pathol. 1985 Sep;120(3):464-77.

Abstract

Histologic findings in mice with severe combined immunodeficiency (SCID) were remarkably uniform, consisting of lymphopenia, a rudimentary thymic medulla without cortex, relatively empty splenic follicles and lymph nodes, and undeveloped bronchial and gastrointestinal lymphocytic foci. Fluorescence-activated cell sorter studies revealed a few T cells (apparently nonfunctional) in thymus and spleen; interestingly, these cells seemed highly disposed to neoplasia, because thymic T-cell lymphomas were observed in 41 of 269 mice. No pre-B or B cells could be identified. Cells of the myeloid lineage appeared normal. Reconstitution of lymphoid tissues was achieved after intravenous injection of histocompatible bone marrow cells.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Antibodies, Monoclonal
  • B-Lymphocytes / pathology
  • Blood Cell Count
  • Bone Marrow Transplantation
  • Cell Separation
  • Disease Models, Animal
  • Flow Cytometry
  • Immunologic Deficiency Syndromes / blood
  • Immunologic Deficiency Syndromes / genetics
  • Immunologic Deficiency Syndromes / pathology*
  • Lung Neoplasms / pathology
  • Lymph Nodes / pathology
  • Lymphoid Tissue / pathology*
  • Lymphoma / pathology
  • Mice
  • Mice, Mutant Strains
  • Neoplasm Metastasis
  • Spleen / pathology
  • Staining and Labeling
  • T-Lymphocytes / pathology
  • Thymus Gland / pathology
  • Thymus Neoplasms / pathology

Substances

  • Antibodies, Monoclonal