Interaction of myelin basic protein with gangliosides and ganglioside-phospholipid mixtures

Biochim Biophys Acta. 1985 Oct 10;819(2):225-30. doi: 10.1016/0005-2736(85)90177-4.

Abstract

The interaction of myelin basic protein with monosialoganglioside GM1 was investigated. It was found that the emission maximum of the tryptophan of the protein is blue-shifted due to the interaction. In mixtures of the monosialoganglioside with phosphatidylcholine, the myelin basic protein induces phase separation of the lipids as inferred from differential scanning calorimetry experiments.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Calorimetry, Differential Scanning
  • G(M1) Ganglioside / metabolism
  • Gangliosides / metabolism*
  • Mathematics
  • Myelin Basic Protein / metabolism*
  • Phospholipids / metabolism*
  • Protein Binding
  • Spectrometry, Fluorescence
  • Swine
  • Tryptophan / analysis

Substances

  • Gangliosides
  • Myelin Basic Protein
  • Phospholipids
  • G(M1) Ganglioside
  • Tryptophan