DNAJ mutations are rare in Chinese Parkinson's disease patients and controls

Neurobiol Aging. 2014 Apr;35(4):935.e1-2. doi: 10.1016/j.neurobiolaging.2013.09.018. Epub 2013 Oct 12.

Abstract

Mutations in DNAJC13, DNAJC6 and DNAJC5 have been implicated in Parkinson's disease (PD). To determine if rare coding variants in these genes play a role in PD risk in the Chinese population, we sequenced all coding exons of the three genes in 99 early-onset PD cases and 99 controls, and genotyped 8 missense variants in another 711 PD cases and 539 controls. Besides two common missense variants that did not show association with PD, the remaining missense variants were extremely rare (<0.5%), found in healthy population controls and did not show enrichment in PD cases. Our results suggest that missense mutations in DNAJC13, DNAJC5 and DNAJC6 do not play a major role in PD in the Chinese population.

Keywords: Association; Chinese population; DNAJ family; Mutation; Parkinson's disease.

MeSH terms

  • Aged
  • Asian Continental Ancestry Group / genetics*
  • Exons / genetics
  • Genotype
  • HSP40 Heat-Shock Proteins / genetics*
  • Humans
  • Male
  • Membrane Proteins / genetics*
  • Middle Aged
  • Molecular Chaperones / genetics*
  • Mutation, Missense / genetics*
  • Parkinson Disease / genetics*

Substances

  • DNAJC13 protein, human
  • DNAJC6 protein, human
  • HSP40 Heat-Shock Proteins
  • Membrane Proteins
  • Molecular Chaperones
  • cysteine string protein