Although the etiology of preterm birth is incompletely understood, phenotype classifications combined with recent technologies such as genome-wide association studies and next-generation sequencing could lead to discovering genotypes associated with preterm birth. Identifying genetic contributions will allow for genetic screening tests to predict or detect pregnancies with potential for preterm birth. In this article we discuss current knowledge regarding phenotype classifications, genotypes, and their associations with preterm birth.
Keywords: GWAS; NGS; SNPs; genetic screening; parturition; premature birth; preterm birth.
© 2013 AWHONN, the Association of Women's Health, Obstetric and Neonatal Nurses.