Long term results of Epi-LASIK and LASEK for myopia

Cont Lens Anterior Eye. 2014 Jun;37(3):132-5. doi: 10.1016/j.clae.2013.09.005. Epub 2013 Oct 13.


Purpose: To evaluate the long term clinical and confocal results of mechanical (Epi-LASIK) versus alcohol-assisted laser epithelial keratomileusis (LASEK) for correction of myopia.

Setting: Gazi University Medical School, Department of Ophthalmology, Ankara, Turkey.

Design: Retrospective study.

Methods: Twenty-two eyes treated with LASEK and twenty eyes treated with Epi-LASIK were evaluated with a mean follow-up duration of 45 months. Mechanical separation of the epithelium was performed with Lasitome epithelial separator, and alcohol-assisted separation with 25s application of 18% alcohol. Laser ablation was performed with the ESIRIS laser. All patients were examined daily until epithelial closure; at 1, 3, 6, and 12 months; and every year subsequently. Main outcome measures were uncorrected visual acuity (UCVA), manifest refraction, haze, and gray scale value in confocal microscopy, efficacy and safety indexes.

Results: Preoperative myopic spherical equivalent refraction was -4.65 ± 1.74 D in the LASEK and -3.87 ± 1.30 D in the Epi-LASIK-treated eyes (p=0.36). Of both LASEK and Epi-LASIK-treated eyes, 95% achieved 20/25 or better final UCVA. The grade of haze and mean gray scale value in confocal microscopy were similar in LASEK and Epi-LASIK-treated eyes at all postoperative periods. The efficacy index was 0.94 in LASEK group and 0.96 in Epi-LASIK group (p=0.44). The safety index was 1.01 in LASEK group and 1.02 in Epi-LASIK group (p=0.42).

Conclusions: Both LASEK and Epi-LASIK offer safe and effective correction of myopia in the long term.

Keywords: Epi-LASIK; LASEK; Long term results.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Female
  • Humans
  • Keratectomy, Subepithelial, Laser-Assisted / methods*
  • Keratomileusis, Laser In Situ / methods*
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Myopia / diagnosis*
  • Myopia / surgery*
  • Recovery of Function
  • Reproducibility of Results
  • Retrospective Studies
  • Sensitivity and Specificity
  • Treatment Outcome
  • Visual Acuity*