Epilepsy surgery outcome and functional network alterations in longitudinal MEG: a minimum spanning tree analysis

Neuroimage. 2014 Feb 1;86:354-63. doi: 10.1016/j.neuroimage.2013.10.010. Epub 2013 Oct 12.

Abstract

Seizure freedom after resective epilepsy surgery is not obtained in a substantial number of patients with medically intractable epilepsy. Functional neural network analysis is a promising technique for more accurate identification of the target areas for epilepsy surgery, but a better understanding of the correlations between changes in functional network organization due to surgery and postoperative seizure status is required. We explored these correlations in longitudinal magnetoencephalography (MEG) recordings of 20 lesional epilepsy patients. Resting-state MEG recordings were obtained at baseline (preoperatively; T0) and at 3-7 (T1) and 9-15months after resection (T2). We assessed frequency-specific functional connectivity and performed a minimum spanning tree (MST) network analysis. The MST captures the most important connections in the network. We found a significant positive correlation between functional connectivity in the lower alpha band and seizure frequency at T0, especially in regions where lesions were located. MST leaf fraction, a measure of integration of information in the network, was significantly increased between T0 and T2, only for the seizure-free patients. This is in line with previous work, which showed that lower functional network integration in lesional epilepsy patients is related to higher epilepsy burden. Finally, eccentricity and betweenness centrality, which are measures of hub-status, decreased between T0 and T2 in seizure free patients, also in regions that were anatomically close to resection cavities. Our results increase insight into functional network changes in successful epilepsy surgery and might eventually be utilized for optimization of neurosurgical approaches.

Keywords: EZ; Functional connectivity; Glioma; Lesional epilepsy; MEG; MST; Magnetoencephalography; Minimum spanning tree; Network analysis; PLI; POS; Resective surgery; SF; epileptogenic zone; magnetoencephalography; minimum spanning tree; phase lag index; post-operative seizures; seizure free.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Algorithms
  • Brain Mapping / methods*
  • Epilepsy / diagnosis
  • Epilepsy / physiopathology*
  • Epilepsy / surgery*
  • Female
  • Humans
  • Longitudinal Studies
  • Magnetoencephalography / methods*
  • Male
  • Nerve Net / physiopathology*
  • Nerve Net / surgery*
  • Outcome Assessment, Health Care / methods*
  • Reproducibility of Results
  • Sensitivity and Specificity
  • Treatment Outcome