Flattening-filter-free intensity modulated breath-hold image-guided SABR (Stereotactic ABlative Radiotherapy) can be applied in a 15-min treatment slot

Radiother Oncol. 2013 Dec;109(3):505-9. doi: 10.1016/j.radonc.2013.09.014. Epub 2013 Oct 12.


Hypofractionated image-guided stereotactic ablative radiotherapy (igSABR) is effective in small lung/liver lesions. Computer-assisted breath-hold reduces intrafraction motion but, as every gating/triggering strategy, reduces the duty cycle, resulting in long fraction times if combined with intensity-modulated radiotherapy (IMRT). 10 MV flattening-filter-free IMRT reduces daily fraction duration to <10 min for single doses of 5-20 Gy.

Keywords: Breath hold; FFF; Image guidance; Lung; SABR.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Breath Holding
  • Cohort Studies
  • Dose Fractionation, Radiation
  • Filtration
  • Humans
  • Middle Aged
  • Radiosurgery / methods*
  • Radiotherapy Dosage
  • Radiotherapy Planning, Computer-Assisted / methods*
  • Radiotherapy, Image-Guided
  • Radiotherapy, Intensity-Modulated / methods
  • Retrospective Studies