Regulation of RIP1 kinase signalling at the crossroads of inflammation and cell death

Nat Rev Mol Cell Biol. 2013 Nov;14(11):727-36. doi: 10.1038/nrm3683. Epub 2013 Oct 16.


Receptor-interacting protein 1 (RIP1) kinase has emerged as a key upstream regulator that controls inflammatory signalling as well as the activation of multiple cell death pathways, including apoptosis and necroptosis. The ability of RIP1 to modulate these key cellular events is tightly controlled by ubiquitylation, deubiquitylation and the interaction of RIP1 with a class of ubiquitin receptors. The modification of RIP1 may thus provide a unique 'ubiquitin code' that determines whether a cell activates nuclear factor-κB (NF-κB) to promote inflammatory signalling or induces cell death by apoptosis or necroptosis. Targeting RIP1 might be a novel therapeutic strategy for the treatment of both acute and chronic human diseases.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Death / physiology*
  • Humans
  • Inflammation / genetics
  • Inflammation / metabolism*
  • Models, Biological
  • NF-kappa B / metabolism
  • Receptor-Interacting Protein Serine-Threonine Kinases / genetics
  • Receptor-Interacting Protein Serine-Threonine Kinases / metabolism*


  • NF-kappa B
  • RIPK1 protein, human
  • Receptor-Interacting Protein Serine-Threonine Kinases