Spatiotemporal drug release visualized through a drug delivery system with tunable aggregation-induced emission

Xiangdong Xue; Yuanyuan Zhao; Luru Dai; Xu Zhang; Xiaohong Hao; Chunqiu Zhang; Shuaidong Huo; Juan Liu; Chang Liu; Anil Kumar; Wei-Qiang Chen; Guozhang Zou; Xing-Jie Liang

doi:10.1002/adma.201302365

Spatiotemporal drug release visualized through a drug delivery system with tunable aggregation-induced emission

Adv Mater. 2014 Feb;26(5):712-7. doi: 10.1002/adma.201302365. Epub 2013 Oct 16.

Authors

Xiangdong Xue¹, Yuanyuan Zhao, Luru Dai, Xu Zhang, Xiaohong Hao, Chunqiu Zhang, Shuaidong Huo, Juan Liu, Chang Liu, Anil Kumar, Wei-Qiang Chen, Guozhang Zou, Xing-Jie Liang

Affiliation

¹ CAS Key Laboratory for Biological Effects of Nanomaterials & Nanosafety National Center for Nanoscience and Technology, No 11 Beiyitiao, Zhongguancun, Beijing, 100190, China.

PMID: 24129910
DOI: 10.1002/adma.201302365

Abstract

Tetraphenylethene and doxorubicin are assembled into a self-indicating drug delivery system (TD NPs). TD NPs are decomposed into DOX and TPE NPs in lysosome. Since TD NPs, TPE NPs and DOX are all fluorescent, the detachment of DOX from TPE NPs is accompanied by fluorescence changing. By observing the fluorescence changes, the spatiotemporal drug release is visualized.

Keywords: aggregation-induced emission; drug delivery system; nanoaggregation; self-indicating nanoparticles; spatiotemporal drug release.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cell Survival / drug effects
Doxorubicin / chemistry
Doxorubicin / toxicity
Drug Carriers / chemistry*
Humans
Hydrogen-Ion Concentration
MCF-7 Cells
Nanoparticles / chemistry

Substances

Drug Carriers
Doxorubicin