Crystallographic characterization of a fully rotated, basic diiron dithiolate: model for the H(red) state?

Wenguang Wang; Thomas B Rauchfuss; Curtis E Moore; Arnold L Rheingold; Luca De Gioia; Giuseppe Zampella

doi:10.1002/chem.201303351

Crystallographic characterization of a fully rotated, basic diiron dithiolate: model for the H(red) state?

Chemistry. 2013 Nov 11;19(46):15476-9. doi: 10.1002/chem.201303351. Epub 2013 Oct 15.

Authors

Wenguang Wang¹, Thomas B Rauchfuss, Curtis E Moore, Arnold L Rheingold, Luca De Gioia, Giuseppe Zampella

Affiliation

¹ Department of Chemistry, University of Illinois, 600 S. Goodwin Ave., Urbana, IL 61801 (USA).

PMID: 24130068
DOI: 10.1002/chem.201303351

Abstract

A lucky break: A combination of steric pressure and electron asymmetry has provided the first example of a diiron dithiolate that is both rotated and basic. The present work establishes the feasibility of a hydride free rotated structure for the Hred state of the enzyme.

Keywords: active site; co-ligands; hydrides; hydrogenase; iron.

Publication types

Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Catalytic Domain
Crystallography, X-Ray
Hydrogenase / chemistry*
Iron / chemistry*
Ligands
Sulfhydryl Compounds / chemistry*

Substances

Ligands
Sulfhydryl Compounds
Iron
Hydrogenase

Grants and funding

R01 GM061153/GM/NIGMS NIH HHS/United States