Effects of collagen tripeptide supplement on skin properties: a prospective, randomized, controlled study

J Cosmet Laser Ther. 2014 Jun;16(3):132-7. doi: 10.3109/14764172.2013.854119. Epub 2013 Nov 18.


Background: Experimental and clinical trials have indicated that dietary supplements can have beneficial effects on skin health.

Objective: We investigated to evaluate the effect of daily collagen peptide (CP) supplement on skin properties.

Methods: Thirty-two healthy volunteers were randomized to receive either no supplement (Group A), CP 3 g (Group B), CP 3 g, and vitamin C 500 mg (Group C), or vitamin C 500 mg (Group D) daily for 12 weeks. Skin properties evaluated included hydration, transepidermal water loss (TEWL), and elasticity using a corneometer, tewameter, and cutometer, respectively.

Results: Changes from baseline in the corneometer were statistically significant between Groups A and B (p = 0.011) and Groups A and C (p = 0.004). There were statistically significant differences in cutometer from baseline between Groups A and B (p = 0.005) and Groups A and C (p = 0.015). There was no significant difference from baseline in the corneometer and cutometer between Groups B and C. The greatest changes in TEWL from baseline were seen in Group B, and the second greatest changes were seen in Group C.

Conclusions: Daily CP supplementation may improve skin hydration and elasticity, but concomitant intake of low-dose vitamin C did not enhance the effect of CP on skin properties.

Keywords: collagen tripeptide; skin elasticity; skin hydration.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Ascorbic Acid / administration & dosage
  • Ascorbic Acid / pharmacology*
  • Collagen / administration & dosage
  • Collagen / pharmacology*
  • Dietary Supplements*
  • Drug Therapy, Combination
  • Elasticity / drug effects
  • Female
  • Humans
  • Male
  • Middle Aged
  • Prospective Studies
  • Republic of Korea
  • Single-Blind Method
  • Skin / drug effects*
  • Water


  • Water
  • Collagen
  • Ascorbic Acid