Response initiation in young adults at risk for psychosis in the Northern Finland 1986 Birth Cohort

Cogn Neuropsychiatry. 2014;19(3):226-40. doi: 10.1080/13546805.2013.840569. Epub 2013 Oct 16.


Introduction: This is one of the very few studies to investigate the specific executive function/processing speed component of response initiation in subjects at familial risk (FR) for psychosis, and the first such study in subjects at clinical risk (CR) for psychosis.

Methods: Participants (N = 177) were members of the general population-based Northern Finland 1986 Birth Cohort in the following four groups: FR for psychosis (n = 62), CR for psychosis (n = 21), psychosis (n = 25) and control subjects (n = 69). The response initiation of these groups was compared in three different tests: Semantic fluency, Stockings of Cambridge and Spatial working memory.

Results: The two risk groups did not differ significantly from control group, but differed from, and outperformed the psychosis group in semantic fluency response initiation.

Conclusions: Response initiation deficits were not evident in a non-help seeking psychosis high-risk sample.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Analysis of Variance
  • Executive Function / physiology*
  • Family Health
  • Female
  • Finland / epidemiology
  • Humans
  • Infant, Newborn
  • Longitudinal Studies
  • Male
  • Memory, Short-Term / physiology*
  • Psychotic Disorders / epidemiology*
  • Psychotic Disorders / physiopathology*
  • Risk Factors
  • Semantics
  • Young Adult