A case of Mycobacterium mucogenicum infection in a liver transplant recipient and a review of the literature

Transpl Infect Dis. 2013 Dec;15(6):E260-3. doi: 10.1111/tid.12154. Epub 2013 Oct 17.

Abstract

Bacterial, viral, and fungal infections can be devastating in a postoperative liver transplant recipient on multidrug immunosuppressive therapy. Various atypical (nontuberculous mycobacteria [NTM]) mycobacterial infections have been reported in the solid organ transplant population, but to our knowledge, no cases of Mycobacterium mucogenicum infections have been reported. Here, we report a case of a patient with end-stage liver disease secondary to primary biliary cirrhosis, model for end-stage liver disease score of 29, who underwent deceased-donor orthotopic liver transplantation, with her postoperative course complicated by multiple pleural effusions and peritonitis. Despite numerous courses of antibiotics, her condition did not improve. Acid-fast bacilli cultures grew M. mucogenicum, which was then treated with appropriate antimicrobical therapy. M. mucogenicum, a rapidly growing NTM that can be present in water contamination, should be recognized as a potential source of infection, especially in the immunocompromised population.

Keywords: Mycobacterium chelonae; Mycobacterium mucogenicum; NTM; liver transplant; nontuberculous mycobacteria; peritonitis.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Anti-Bacterial Agents / therapeutic use
  • Ascites / microbiology
  • Female
  • Humans
  • Immunosuppression Therapy / adverse effects*
  • Liver Transplantation / adverse effects
  • Middle Aged
  • Mycobacterium Infections, Nontuberculous / drug therapy*
  • Mycobacterium Infections, Nontuberculous / microbiology*
  • Nontuberculous Mycobacteria*
  • Pleural Effusion / microbiology

Substances

  • Anti-Bacterial Agents