Abstract
The influence of the microenvironment on tumour progression is becoming clearer. In this Review we address the role of an essential signalling pathway, that of transforming growth factor-β, in the regulation of components of the tumour microenvironment and how this contributes to tumour progression.
Publication types
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Research Support, N.I.H., Extramural
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Review
MeSH terms
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Adaptive Immunity
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Animals
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Cell Movement
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Disease Progression
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Epigenesis, Genetic
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Fibroblasts / metabolism
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Gene Expression Regulation, Neoplastic*
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Humans
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Immunity, Innate
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Mice
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Neoplasms / genetics*
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Phenotype
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Signal Transduction
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Stromal Cells / metabolism
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Transforming Growth Factor beta / metabolism*
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Tumor Microenvironment*
Substances
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Transforming Growth Factor beta