The roles of TGFβ in the tumour microenvironment

Nat Rev Cancer. 2013 Nov;13(11):788-99. doi: 10.1038/nrc3603. Epub 2013 Oct 17.


The influence of the microenvironment on tumour progression is becoming clearer. In this Review we address the role of an essential signalling pathway, that of transforming growth factor-β, in the regulation of components of the tumour microenvironment and how this contributes to tumour progression.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Adaptive Immunity
  • Animals
  • Cell Movement
  • Disease Progression
  • Epigenesis, Genetic
  • Fibroblasts / metabolism
  • Gene Expression Regulation, Neoplastic*
  • Humans
  • Immunity, Innate
  • Mice
  • Neoplasms / genetics*
  • Phenotype
  • Signal Transduction
  • Stromal Cells / metabolism
  • Transforming Growth Factor beta / metabolism*
  • Tumor Microenvironment*


  • Transforming Growth Factor beta