Criteria for the use of omics-based predictors in clinical trials

Nature. 2013 Oct 17;502(7471):317-20. doi: 10.1038/nature12564.


The US National Cancer Institute (NCI), in collaboration with scientists representing multiple areas of expertise relevant to 'omics'-based test development, has developed a checklist of criteria that can be used to determine the readiness of omics-based tests for guiding patient care in clinical trials. The checklist criteria cover issues relating to specimens, assays, mathematical modelling, clinical trial design, and ethical, legal and regulatory aspects. Funding bodies and journals are encouraged to consider the checklist, which they may find useful for assessing study quality and evidence strength. The checklist will be used to evaluate proposals for NCI-sponsored clinical trials in which omics tests will be used to guide therapy.

MeSH terms

  • Checklist
  • Clinical Trials as Topic / economics
  • Clinical Trials as Topic / ethics
  • Clinical Trials as Topic / methods*
  • Clinical Trials as Topic / standards
  • Evaluation Studies as Topic
  • Genomics* / ethics
  • Humans
  • Models, Biological
  • National Cancer Institute (U.S.) / economics
  • Precision Medicine / ethics
  • Precision Medicine / methods
  • Precision Medicine / standards
  • Research Design* / standards
  • Specimen Handling
  • United States