Hypolipemic Effect of Garcinia Cambogia in Obese Women

Phytother Res. 2014 Jun;28(6):887-91. doi: 10.1002/ptr.5076. Epub 2013 Oct 17.

Abstract

Garcinia cambogia seems to promote weight reduction and improvement on lipid profile by its major compound, hydroxycitric acid (HCA), blocking ATP-citratelyase, potentially inhibiting lipogenesis. Furthermore, it is suggested that its extract is able to change the adipokine levels. Thus, the aim of this study was to analyse the effect of G. cambogia on the lipid profile, endocrine, calorimetric and anthropometric parameters of obese women. The women (BMI > 25 kg/m(2) ; age 25-60 years), divided in treated (n = 30) and control (n = 13) groups, received 2.4 g (800 mg 3×/day) of garcinia extract (50% of HCA) or placebo during 60 days, respectively, as well as dietary control. Weight, BMI, waist-hip ratio and percentage of fat mass, resting metabolic rate, respiratory coefficient, triglycerides (TG), total cholesterol, HDL and LDL, leptin and insulin serum levels were evaluated. TG was significantly reduced in the treated group (p = 0.0002) and the post-treatment variation was different compared to the placebo group (p = 0.04). No significant response was observed on other variables of the lipid profile, or on the anthropometric and calorimetric parameters. Leptin and insulin levels did not change significantly after the treatment. The short-term treatment with G. cambogia demonstrated a hypotriglyceridemic effect, which does not appear to be related to changes in leptinemia.

Keywords: Garcinia cambogia; leptin; lipid profile; obesity.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Cholesterol / blood
  • Double-Blind Method
  • Female
  • Garcinia cambogia / chemistry*
  • Humans
  • Hypolipidemic Agents / pharmacology*
  • Insulin / blood
  • Leptin / blood
  • Middle Aged
  • Obesity / blood*
  • Plant Extracts / pharmacology*
  • Triglycerides / blood

Substances

  • Hypolipidemic Agents
  • Insulin
  • Leptin
  • Plant Extracts
  • Triglycerides
  • Cholesterol