[Malignant hyperthermia: multifactorial events leading to a crisis]

Ann Fr Anesth Reanim. 2013 Nov;32(11):792-5. doi: 10.1016/j.annfar.2013.07.819. Epub 2013 Oct 14.
[Article in French]


This case-report focused on the occurrence of a crisis of malignant hyperthermia on a young biker (21 y.o.) victim of a severe traffic accident. This observation gives some key points: the delayed occurrence of the crisis after 4 hours of surgery, the multi-factorial events that triggered the crisis; the choice to perform a quick diagnosis through gene analysis in comparison to the standard tests of caffeine on a muscular biopsy. These different points are discussed with a proposal of algorithm in the situation.

Keywords: Diagnostic génétique; Genetic diagnosis; Hyperthermie maligne; Malignant hyperthermia; Polytrauma; Polytraumatisme.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Accidents, Traffic
  • Algorithms
  • Bicycling / injuries
  • Biopsy
  • Caffeine
  • Central Nervous System Stimulants
  • Genetic Predisposition to Disease / genetics*
  • Humans
  • Male
  • Malignant Hyperthermia / diagnosis*
  • Malignant Hyperthermia / drug therapy*
  • Malignant Hyperthermia / therapy
  • Multiple Trauma / therapy
  • Respiration, Artificial
  • Rhabdomyolysis / etiology
  • Rhabdomyolysis / therapy
  • Young Adult


  • Central Nervous System Stimulants
  • Caffeine