Thrombotic thrombocytopenic purpura: 2012 American Society for Apheresis (ASFA) consensus conference on classification, diagnosis, management, and future research

J Clin Apher. 2014 Jun;29(3):148-67. doi: 10.1002/jca.21302. Epub 2013 Oct 17.


The American Society for Apheresis (ASFA) conducted a 1 day consensus conference on Thrombotic Thrombocytopenic Purpura (TTP) during its annual meeting in Atlanta, GA, on April 10, 2012. The authors of this article, a subcommittee of ASFA's Clinical Applications Committee, developed several questions with regard to definitions, classification, pathophysiology, diagnosis, management, and future research in TTP. These questions were provided to the seven invited speakers who are the experts in the field of TTP. Two moderators conducted the proceedings of the conference which was attended by more than 100 participants. After each presentation, there was an open discussion that included moderator-selected written questions submitted by the audience. A medical writer-generated transcript of the proceedings as well as each presentation was made available to the authors. Each summary was reviewed and approved by the respective speaker before submission of this article. The subcommittee also developed seven key questions for blinded, electronic polling conducted by the moderators to generate a consensus amongst the speakers. This article includes these presentation summaries as well as results of the electronic poll.

Keywords: ADAMTS13; Upshaw Shulman Syndrome; microangiopathic hemolytic anemia; therapeutic plasma exchange; thrombotic thrombocytopenic purpura.

Publication types

  • Consensus Development Conference

MeSH terms

  • ADAM Proteins / blood
  • ADAM Proteins / deficiency
  • ADAMTS13 Protein
  • Blood Component Removal
  • Humans
  • Plasma Exchange
  • Platelet Transfusion
  • Purpura, Thrombotic Thrombocytopenic* / classification
  • Purpura, Thrombotic Thrombocytopenic* / diagnosis
  • Purpura, Thrombotic Thrombocytopenic* / therapy
  • Societies, Scientific
  • United States


  • ADAM Proteins
  • ADAMTS13 Protein
  • ADAMTS13 protein, human