Explosive type of moderate-resistance training induces functional, cardiovascular, and molecular adaptations in the elderly

Age (Dordr). 2014 Apr;36(2):759-72. doi: 10.1007/s11357-013-9584-1. Epub 2013 Oct 18.


Current recommendations aimed at reducing neuromuscular and functional loss in aged muscle have identified muscle power as a key target for intervention trials, although little is known about the biological and cardiovascular systemic response in the elderly. This study investigated the effects of 12 weeks of low-frequency, moderate-intensity, explosive-type resistance training (EMRT) on muscle strength and power in old community-dwelling people (70-75 years), monitoring functional performance linked to daily living activities (ADL) and cardiovascular response, as well as biomarkers of muscle damage, cardiovascular risk, and cellular stress response. The present study provides the first evidence that EMRT was highly effective in achieving a significant enhancement in muscular strength and power as well as in functional performance without causing any detrimental modification in cardiovascular, inflammatory, and damage parameters. Moreover, trained elderly subjects showed an adaptive response at both systemic and cellular levels by modulation of antioxidant and stress-induced markers such as myeloperoxidase (MPO), heat shock protein 70 (Hsp70) and 27 (Hsp27), and thioredoxin reductase 1 (TrxR1).

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Activities of Daily Living
  • Adaptation, Physiological / physiology*
  • Aged
  • Aging / physiology*
  • Blotting, Western
  • Cytokines / blood
  • Enzyme-Linked Immunosorbent Assay
  • Exercise / physiology*
  • Exercise Test
  • Female
  • Follow-Up Studies
  • HSP27 Heat-Shock Proteins / blood
  • HSP70 Heat-Shock Proteins / blood
  • Hemodynamics / physiology*
  • Humans
  • Male
  • Muscle Strength / physiology*
  • Muscle, Skeletal / physiology*
  • Natriuretic Peptide, Brain / blood
  • Oxidative Stress / physiology
  • Peptide Fragments / blood
  • Peroxidase / blood
  • Reference Values
  • Resistance Training / methods*
  • Thioredoxin Reductase 1 / blood
  • Walking / physiology


  • Cytokines
  • HSP27 Heat-Shock Proteins
  • HSP70 Heat-Shock Proteins
  • Peptide Fragments
  • pro-brain natriuretic peptide (1-76)
  • Natriuretic Peptide, Brain
  • Peroxidase
  • Thioredoxin Reductase 1