Mechanisms of hemostimulating effect of Aconitum baicalense diterpene alkaloids

Bull Exp Biol Med. 2013 Jul;155(3):350-3. doi: 10.1007/s10517-013-2151-z.

Abstract

A mixture of diterpene alkaloids of Aconitum baicalense exhibited pronounced regenerative hemostimulating properties on the model of cytostatic myelosuppression. The therapeutic effect is based on activation of hemopoietic progenitor cells against the background of increased feeder capacity of stromal compartment of the hemopoiesis-inducing microenvironment and decreased count of mesenchymal stem cells in the bone marrow.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aconitum / chemistry*
  • Alkaloids / analysis
  • Alkaloids / pharmacology*
  • Animals
  • Bone Marrow Cells / drug effects
  • Cellular Microenvironment
  • Diterpenes / analysis
  • Diterpenes / pharmacology*
  • Fluorouracil
  • Hematopoiesis / drug effects*
  • Hematopoietic Stem Cells / drug effects*
  • Mice
  • Regenerative Medicine / methods*

Substances

  • Alkaloids
  • Diterpenes
  • Fluorouracil