Ureaplasma--Are you sitting comfortably?

J Infect. 2014 Jan;68 Suppl 1:S19-23. doi: 10.1016/j.jinf.2013.09.027. Epub 2013 Oct 17.


The role of Ureaplasma spp. in human disease has been controversial, as these bacteria are commonly isolated as part of the normal genital tract flora. Ureaplasma has been shown to have a causal role in urogenital infections and is associated with significant foetal and neonatal morbidity and mortality when infection occurs during the perinatal period. Although rare, invasive Ureaplasma infection (meningitis, renal abscess, mediastinitis and arthritis) has also been reported in both adults and children. This review outlines the unique microbiological features and various clinical presentations of Ureaplasma infection. It also discusses the treatment options, which in the neonatal period can be particularly challenging.

Keywords: Child; Genitourinary; Macrolide; Meningitis; Mycoplasma; Neonate; Newborn; Perinatal infections; Pregnancy.

Publication types

  • Review

MeSH terms

  • Female
  • Female Urogenital Diseases / complications
  • Female Urogenital Diseases / epidemiology*
  • Female Urogenital Diseases / microbiology
  • Female Urogenital Diseases / pathology*
  • Humans
  • Male
  • Male Urogenital Diseases / complications
  • Male Urogenital Diseases / epidemiology*
  • Male Urogenital Diseases / microbiology
  • Male Urogenital Diseases / pathology*
  • Prevalence
  • Survival Analysis
  • Ureaplasma / isolation & purification*
  • Ureaplasma Infections / epidemiology*
  • Ureaplasma Infections / microbiology
  • Ureaplasma Infections / pathology*