Is RNA interference a physiologically relevant innate antiviral immune response in mammals?

Cell Host Microbe. 2013 Oct 16;14(4):374-8. doi: 10.1016/j.chom.2013.09.011.


While RNA interference (RNAi) functions as an antiviral response in plants, nematodes, and arthropods, a similar antiviral role in mammals has remained controversial. Three recent papers provide evidence that either favors or challenges this hypothesis. Here, we discuss these new findings in the context of previous research.

Publication types

  • Review

MeSH terms

  • Animals
  • Gene Expression Regulation, Viral / drug effects*
  • Humans
  • Immunity, Innate*
  • Mammals / immunology*
  • RNA Interference*
  • RNA Viruses / immunology*