Lipids in innate antiviral defense

Cell Host Microbe. 2013 Oct 16;14(4):379-85. doi: 10.1016/j.chom.2013.09.010.


It is becoming apparent that infections by a major class of viruses, those with envelopes, can be inhibited during their entry at the step of fusion with cellular membranes. In this review, we discuss multiple innate immune mechanisms that have evolved to modify the lipid composition of cellular and viral membranes to inhibit virion fusion of enveloped viruses.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Humans
  • Immunity, Innate*
  • Membrane Lipids / metabolism*
  • Virus Diseases / immunology*
  • Virus Internalization*
  • Viruses*


  • Membrane Lipids