Progress in translational research on intracerebral hemorrhage: is there an end in sight?

Prog Neurobiol. 2014 Apr;115:45-63. doi: 10.1016/j.pneurobio.2013.09.007. Epub 2013 Oct 16.


Intracerebral hemorrhage (ICH) is a common and often fatal stroke subtype for which specific therapies and treatments remain elusive. To address this, many recent experimental and translational studies of ICH have been conducted, and these have led to several ongoing clinical trials. This review focuses on the progress of translational studies of ICH including those of the underlying causes and natural history of ICH, animal models of the condition, and effects of ICH on the immune and cardiac systems, among others. Current and potential clinical trials also are discussed for both ICH alone and with intraventricular extension.

Keywords: Animal models; Brain edema; Intracerebral hemorrhage; Iron.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Cerebral Hemorrhage / complications
  • Cerebral Hemorrhage / therapy*
  • Disease Models, Animal
  • Humans
  • Inflammation / etiology
  • Inflammation / therapy
  • Translational Research, Biomedical*