PPARalpha regulates the production of serum Vanin-1 by liver

FEBS Lett. 2013 Nov 15;587(22):3742-8. doi: 10.1016/j.febslet.2013.09.046. Epub 2013 Oct 15.


The membrane-bound Vanin-1 pantetheinase regulates tissue adaptation to stress. We investigated Vnn1 expression and its regulation in liver. Vnn1 is expressed by centrolobular hepatocytes. Using novel tools, we identify a soluble form of Vnn1 in mouse and human serum and show the contribution of a cysteine to its catalytic activity. We show that liver contributes to Vanin-1 secretion in serum and that PPARalpha is a limiting factor in serum Vnn1 production. Functional PPRE sites are identified in the Vnn1 promoter. These results indicate that serum Vnn1 might be a reliable reporter of PPARalpha activity in liver.

Keywords: Liver; PPARalpha; Pantetheinase; Vanin.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amidohydrolases / blood*
  • Amidohydrolases / genetics
  • Animals
  • Caco-2 Cells
  • Female
  • GPI-Linked Proteins / blood
  • GPI-Linked Proteins / genetics
  • Gene Expression
  • Gene Expression Regulation
  • Hepatocytes / enzymology
  • Hepatocytes / metabolism
  • Humans
  • Liver / cytology
  • Liver / enzymology*
  • Male
  • Mice
  • Mice, Inbred C57BL
  • PPAR alpha / metabolism*


  • GPI-Linked Proteins
  • PPAR alpha
  • Amidohydrolases
  • pantetheinase