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. 2013 Dec 26;178(2):217-25.
doi: 10.1016/j.virusres.2013.10.005. Epub 2013 Oct 17.

Comparative Analysis of Error-Prone Replication Mononucleotide Repeats Across Baculovirus Genomes

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Comparative Analysis of Error-Prone Replication Mononucleotide Repeats Across Baculovirus Genomes

David C Ream et al. Virus Res. .
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Abstract

Genome replication by the baculovirus DNA polymerase often generates errors in mononucleotide repeat (MNR) sequences due to replication slippage. This results in the inactivation of genes that affects different stages of the cell infection cycle. Here we mapped these MNRs in the 59 baculovirus genomes. We found that the MNR frequencies of baculovirus genomes are different and not correlated with the genome sizes. Although the average A/T content of baculoviruses is 58.67%, the A/T MNR frequency is significantly higher than that of the G/C MNRs. Furthermore, the A7/T7 MNRs are the most frequent of those we studied. Finally, MNR frequencies in different classes of baculovirus genes, such as immediate early genes, show differences between baculovirus genomes, suggesting that the distribution and frequency of different MNRs are unique to each baculovirus species or strain. Therefore, the results of this study can help select appropriate baculoviruses for the development of biological insecticides.

Keywords: Replication slippage; Viral genome evolution; Viral genome replication; fp25k acquisition.

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