Waddlia chondrophila: from biology to pathogenicity

Microbes Infect. 2013 Dec;15(14-15):1033-41. doi: 10.1016/j.micinf.2013.09.010. Epub 2013 Oct 18.

Abstract

Waddlia chondrophila is an emerging pathogen causing miscarriages in humans and abortions in ruminants. The full genome of this Chlamydia-related bacterium has been recently completed, providing new insights into its biology and evolution. Moreover, new cell biology approaches and the use of novel inhibitors have allowed detailed investigations of its interaction with host cells.

Keywords: Abs; BCV; Chlamydia-related organism; EBs; ER; Intracellular bacteria; OMP; PG; Pathogenesis; RBs; T3SS; Waddlia chondrophila; aberrant bodies; bacteria containing vacuole; elementary bodies; endoplasmic reticulum; outer membrane protein; p.i.; peptidoglycan; post infection; reticulate bodies; type III secretion system.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Abortion, Spontaneous / microbiology
  • Abortion, Veterinary / microbiology
  • Animals
  • Biological Evolution
  • Cell Line
  • Cell Wall / genetics
  • Cell Wall / metabolism
  • Chlamydia / pathogenicity
  • Chlamydia / physiology*
  • Chlamydia Infections / microbiology
  • Energy Metabolism
  • Genome, Bacterial
  • Host-Pathogen Interactions
  • Humans
  • Intracellular Space / microbiology
  • Respiratory Tract Diseases / microbiology