An excitable signal integrator couples to an idling cytoskeletal oscillator to drive cell migration

Nat Cell Biol. 2013 Nov;15(11):1307-16. doi: 10.1038/ncb2859. Epub 2013 Oct 20.


It is generally believed that cytoskeletal activities drive random cell migration, whereas signal transduction events initiated by receptors regulate the cytoskeleton to guide cells. However, we find that the cytoskeletal network, involving SCAR/WAVE, Arp 2/3 and actin-binding proteins, is capable of generating only rapid oscillations and undulations of the cell boundary. The signal transduction network, comprising multiple pathways that include Ras GTPases, PI(3)K and Rac GTPases, is required to generate the sustained protrusions of migrating cells. The signal transduction network is excitable, exhibiting wave propagation, refractoriness and maximal response to suprathreshold stimuli, even in the absence of the cytoskeleton. We suggest that cell motility results from coupling of 'pacemaker' signal transduction and 'idling motor' cytoskeletal networks, and various guidance cues that modulate the threshold for triggering signal transduction events are integrated to control the mode and direction of migration.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Movement*
  • Cytoskeleton / metabolism*
  • GTP Phosphohydrolases / metabolism
  • Humans
  • Models, Biological
  • Phosphatidylinositol 3-Kinases / metabolism
  • Signal Transduction*


  • Phosphatidylinositol 3-Kinases
  • GTP Phosphohydrolases