Central nervous system manifestations of neonatal lupus: a systematic review

Lupus. 2013 Dec;22(14):1484-8. doi: 10.1177/0961203313509294. Epub 2013 Oct 18.


Neonatal lupus is a rare and acquired autoimmune disease. Central nervous system abnormalities are potential manifestations in neonatal lupus. Through a systematic literature review, we analyzed the clinical features of previously reported neonatal lupus cases where central nervous system abnormalities had been identified. Most reported neonatal lupus patients with central nervous system involvement were neuroimaging-determined and asymptomatic. Only seven neonatal lupus cases were identified as having a symptomatic central nervous system abnormality which caused physical disability or required neurosurgery. A high percentage of these neurosymptomatic neonatal lupus patients had experienced a transient cutaneous skin rash and had no maternal history of autoimmune disease before pregnancy.

Keywords: Neonate; autoimmune disease; central nervous system; neonatal lupus.

Publication types

  • Review
  • Systematic Review

MeSH terms

  • Female
  • Humans
  • Infant, Newborn
  • Lupus Erythematosus, Systemic / congenital*
  • Lupus Erythematosus, Systemic / physiopathology
  • Lupus Vasculitis, Central Nervous System / congenital
  • Lupus Vasculitis, Central Nervous System / physiopathology*
  • Lupus Vasculitis, Central Nervous System / surgery
  • Neurosurgical Procedures / methods
  • Pregnancy

Supplementary concepts

  • Neonatal Systemic lupus erythematosus