Abstract
A series of novel ligustrazine-benzoic acid derivatives were synthesized and evaluated for their protective effect against cobalt chloride-induced neurotoxicity in differentiated PC12 cells. Combining hematoxylin and eosin staining, we found compound that (3,5,6-trimethylpyrazin-2-yl)methyl 3-methoxy-4-[(3,5,6-trimethylpyrazin-2-yl)methoxy]benzoate (4a) displayed promising protective effect on the proliferation of the injured PC12 cells (EC50 = 4.249 µM). Structure-activity relationships are briefly discussed.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Benzoates / chemical synthesis*
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Benzoates / pharmacology
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Cell Differentiation
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Cell Proliferation
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Cell Survival / drug effects
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Cobalt / toxicity
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Inhibitory Concentration 50
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Neurons / drug effects
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Neurons / physiology*
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Neuroprotective Agents / chemical synthesis
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Neuroprotective Agents / pharmacology
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PC12 Cells
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Pyrazines / chemistry*
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Rats
Substances
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Benzoates
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Neuroprotective Agents
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Pyrazines
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Cobalt
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cobaltous chloride
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tetramethylpyrazine