Extract of Perilla frutescens inhibits tumor proliferation of HCC via PI3K/AKT signal pathway

Afr J Tradit Complement Altern Med. 2012 Dec 31;10(2):251-7. eCollection 2013.

Abstract

In this study, isoegomaketone(IK) was isolated from Perilla frutescens(L.), a Chinese herbal. The effects of IK were examined by cell viability assay, colony formation assay, xenograft tumor assay and western blotting in HCC cells. We found that IK inhibited cell viability, and its administration decreased tumor volume and weight profoundly. The presence of IK(10 nmol/l) produced a dramatic decrease of pAkt, while total Akt level was not affected. The data suggested that IK from perilla suppressed HCC tumor growth via blocking PI3K/Akt signaling pathway.

Keywords: HCC; IK; PI3K/AKT; Perilla Frutescens; Tumor Proliferation.

MeSH terms

  • Animals
  • Antineoplastic Agents, Phytogenic / pharmacology
  • Antineoplastic Agents, Phytogenic / therapeutic use*
  • Carcinoma, Hepatocellular / drug therapy*
  • Carcinoma, Hepatocellular / metabolism
  • Cell Line, Tumor
  • Cell Proliferation / drug effects
  • Furans / isolation & purification
  • Furans / pharmacology
  • Furans / therapeutic use*
  • Ketones / isolation & purification
  • Ketones / pharmacology
  • Ketones / therapeutic use*
  • Liver Neoplasms / drug therapy*
  • Liver Neoplasms / metabolism
  • Liver Neoplasms, Experimental / drug therapy
  • Liver Neoplasms, Experimental / metabolism
  • Mice
  • Mice, Inbred BALB C
  • Mice, Nude
  • Perilla frutescens / chemistry*
  • Phosphatidylinositol 3-Kinases / metabolism
  • Phytotherapy*
  • Plant Extracts / pharmacology
  • Plant Extracts / therapeutic use
  • Proto-Oncogene Proteins c-akt / metabolism*
  • Signal Transduction
  • Xenograft Model Antitumor Assays

Substances

  • Antineoplastic Agents, Phytogenic
  • Furans
  • Ketones
  • Plant Extracts
  • isoegomaketone
  • Phosphatidylinositol 3-Kinases
  • Proto-Oncogene Proteins c-akt