Hematological and hemorheological determinants of the six-minute walk test performance in children with sickle cell anemia

PLoS One. 2013 Oct 17;8(10):e77830. doi: 10.1371/journal.pone.0077830. eCollection 2013.

Abstract

The six-minute walk test is a well-established submaximal exercise reflecting the functional status and the clinical severity of sickle cell patients. The aim of the present cross-sectional study was to investigate the biological determinants of the six-minute walk test performance in children with sickle cell anemia. Hematological and hemorheological parameters, pulmonary function and the six-minute walk test performance were determined in 42 children with sickle cell anemia at steady state. The performance during the six-minute walk test was normalized for age, sex and height and expressed as percentage of the predicted six-minute walk distance. We showed that a high level of anemia, a low fetal hemoglobin expression and low red blood cell deformability were independent predictors of a low six-minute walk test performance. This study describes for the first time the impact of blood rheology in the six-minute walk test performance in children with sickle cell anemia.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Anemia, Sickle Cell / metabolism*
  • Anemia, Sickle Cell / pathology*
  • Anemia, Sickle Cell / physiopathology
  • Child
  • Erythrocytes / pathology
  • Exercise Test / methods*
  • Female
  • Fetal Hemoglobin / metabolism
  • Humans
  • Male
  • Walking / physiology*

Substances

  • Fetal Hemoglobin

Grant support

This work was supported by the “Projet Hospitalier de Recherche Clinique Interregional” (PHRC). X.W. thesis was funded by the regional council of Guadeloupe. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.