The fifth biennial Berry Health Benefits Symposium showcased recent research supporting the positive effects of berry consumption on human health and disease. Remarkably, the vast majority of oral papers covered data accumulated from in vivo studies, which underscores how berry health research has advanced since the inception of this symposium in 2005. Similar to the past, research presented at this meeting was primarily focused on the major commercially cultivated berries in North America, namely, blackberry, blueberry, black raspberry, cranberry, red raspberry, and strawberry. Despite this, on the basis of similar compositional chemistry, it is possible that similar biological effects may also be extended to other small soft-fleshed "berry-type" fruits popular in other parts of the world including Europe, Asia, and South America. Overall, this symposium continues to add to the growing body of data supporting the positive impact of berry fruit consumption on human health promotion and disease risk reduction.