Variation at 3p24.1 and 6q23.3 influences the risk of Hodgkin's lymphoma

Nat Commun. 2013;4:2549. doi: 10.1038/ncomms3549.

Abstract

In addition to HLA, recent genome-wide association studies (GWASs) of Hodgkin's lymphoma (HL) have identified susceptibility loci for HL at 2p16.1, 8q24.21 and 10p14. In this study, we perform a GWAS meta-analysis with published GWAS (totalling 1,465 cases and 6,417 controls of European background), and follow-up the most significant association signals in 2,024 cases and 1,853 controls. A combined analysis identifies new HL susceptibility loci mapping to 3p24.1 (rs3806624; P=1.14 × 10(-12), odds ratio (OR)=1.26) and 6q23.3 (rs7745098; P=3.42 × 10(-9), OR=1.21). rs3806624 localizes 5' to the EOMES (eomesodermin) gene within a p53 response element affecting p53 binding. rs7745098 maps intergenic to HBS1L and MYB, a region previously associated with haematopoiesis. These findings provide further insight into the genetic and biological basis of inherited susceptibility to HL.

Publication types

  • Meta-Analysis
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Case-Control Studies
  • Chromosomes, Human, Pair 3 / genetics*
  • Chromosomes, Human, Pair 6 / genetics*
  • European Continental Ancestry Group
  • Gene Expression
  • Gene Frequency
  • Genetic Loci
  • Genetic Predisposition to Disease*
  • Genome-Wide Association Study
  • Hodgkin Disease / ethnology
  • Hodgkin Disease / genetics*
  • Hodgkin Disease / pathology
  • Humans
  • Odds Ratio
  • Polymorphism, Single Nucleotide*
  • T-Box Domain Proteins / genetics
  • Tumor Suppressor Protein p53 / genetics

Substances

  • EOMES protein, human
  • T-Box Domain Proteins
  • Tumor Suppressor Protein p53