Delivery materials for siRNA therapeutics

Nat Mater. 2013 Nov;12(11):967-77. doi: 10.1038/nmat3765.


RNA interference (RNAi) has broad potential as a therapeutic to reversibly silence any gene. To achieve the clinical potential of RNAi, delivery materials are required to transport short interfering RNA (siRNA) to the site of action in the cells of target tissues. This Review provides an introduction to the biological challenges that siRNA delivery materials aim to overcome, as well as a discussion of the way that the most effective and clinically advanced classes of siRNA delivery systems, including lipid nanoparticles and siRNA conjugates, are designed to surmount these challenges. The systems that we discuss are diverse in their approaches to the delivery problem, and provide valuable insight to guide the design of future siRNA delivery materials.

Publication types

  • Review

MeSH terms

  • Animals
  • Drug Carriers / chemistry*
  • Humans
  • Nanoparticles / chemistry
  • RNA, Small Interfering / chemistry
  • RNA, Small Interfering / genetics
  • RNA, Small Interfering / therapeutic use*


  • Drug Carriers
  • RNA, Small Interfering