Clinical presentation and differential diagnosis of dementia with Lewy bodies: a review

Int J Geriatr Psychiatry. 2014 Jun;29(6):569-76. doi: 10.1002/gps.4039. Epub 2013 Oct 21.

Abstract

Background: Dementia with Lewy bodies is one of the most prevalent dementia diagnoses. However, differential diagnosis between dementia with Lewy bodies, Alzheimer's disease, and Parkinson's disease with dementia can still be very difficult given the overlap in neuropathology, clinical presentation, cognitive, and neuroanatomical changes.

Method: A literature review of dementia with Lewy bodies, Alzheimer's disease, and Parkinson's disease with dementia was conducted using PubMed.

Results and implications: Accurate diagnosis of dementia with Lewy bodies is crucial in order to more accurately predict the progression of the disease and negative side effects from pharmacological treatment. The differences and similarities between dementia with Lewy bodies, Alzheimer's disease, and Parkinson's disease with dementia are highlighted in order to aid clinicians in differential diagnosis.

Keywords: aging; alpha synucleins; dementia; dementia with Lewy bodies; differential diagnosis.

Publication types

  • Review

MeSH terms

  • Alzheimer Disease / diagnosis*
  • Alzheimer Disease / pathology
  • Alzheimer Disease / psychology
  • Diagnosis, Differential
  • Humans
  • Lewy Body Disease / diagnosis*
  • Lewy Body Disease / pathology
  • Lewy Body Disease / psychology
  • Neuropsychological Tests
  • Parkinson Disease / diagnosis*
  • Parkinson Disease / pathology
  • Parkinson Disease / psychology