Catalytic enantioselective synthesis of functionalized tropanes reveals novel inhibitors of hedgehog signaling

Abstract

Dipolar cycloaddition: A highly efficient copper(I)-catalyzed enantioselective [3+2] cycloaddition reaction of 1,3-fused cyclic azomethine ylides and nitroalkenes has been developed. This method provides access to functionalized tropane scaffolds with several quaternary and tertiary stereocenters in a single step under mild reaction conditions.

Keywords: asymmetric catalysis; cycloaddition; hedgehog pathway; nitroalkenes; tropanes.