Chromatin dynamics during cellular reprogramming

Nature. 2013 Oct 24;502(7472):462-71. doi: 10.1038/nature12749.


Induced pluripotency is a powerful tool to derive patient-specific stem cells. In addition, it provides a unique assay to study the interplay between transcription factors and chromatin structure. Here, we review the latest insights into chromatin dynamics that are inherent to induced pluripotency. Moreover, we compare and contrast these events with other physiological and pathological processes that involve changes in chromatin and cell state, including germ cell maturation and tumorigenesis. We propose that an integrated view of these seemingly diverse processes could provide mechanistic insights into cell fate transitions in general and might lead to new approaches in regenerative medicine and cancer treatment.

Publication types

  • Review

MeSH terms

  • Animals
  • Carcinogenesis / genetics
  • Cell Differentiation / genetics
  • Cell Fusion
  • Cellular Reprogramming*
  • Chromatin / genetics*
  • Chromatin / metabolism*
  • DNA Methylation
  • Epigenesis, Genetic
  • Germ Cells / cytology
  • Germ Cells / metabolism
  • Histones / metabolism
  • Humans
  • Induced Pluripotent Stem Cells / cytology
  • Induced Pluripotent Stem Cells / metabolism
  • Nuclear Transfer Techniques
  • Signal Transduction
  • Transcription Factors / metabolism


  • Chromatin
  • Histones
  • Transcription Factors