Association Between Prenatal Polychlorinated Biphenyl Exposure and Obesity Development at Ages 5 and 7 Y: A Prospective Cohort Study of 656 Children From the Faroe Islands

Am J Clin Nutr. 2014 Jan;99(1):5-13. doi: 10.3945/ajcn.113.066720. Epub 2013 Oct 23.

Abstract

Background: Chemicals with endocrine-disrupting abilities may act as obesogens and interfere with the body's natural weight-control mechanisms, especially if exposure occurs during prenatal life.

Objective: We examined the association between prenatal exposure to polychlorinated biphenyls (PCBs) and p,p'-dichlorodiphenyldichloroethylene (DDE) and subsequent obesity at 5 and 7 y of age.

Design: From 1997 to 2000, 656 pregnant Faroese women were recruited. PCB and DDE were measured in maternal serum and breast milk, and children's weight, height, and waist circumference (WC) were measured at clinical examinations at 5 and 7 y of age. The change in body mass index (BMI) from 5 to 7 y of age was calculated. Analyses were performed by using multiple linear regression models for girls and boys separately, taking into account maternal prepregnancy BMI.

Results: For 7-y-old girls who had overweight mothers, PCB was associated with increased BMI (β = 2.07, P = 0.007), and PCB and DDE were associated with an increased change in BMI from 5 to 7 y of age (PCB: β = 1.23, P = 0.003; DDE: β = 1.11, P = 0.008). No association was observed with BMI in girls with normal-weight mothers. PCB was associated with increased WC in girls with overweight mothers (β = 2.48, P = 0.001) and normal-weight mothers (β = 1.25, P = 0.04); DDE was associated with increased WC only in girls with overweight mothers (β = 2.21, P = 0.002). No associations were observed between PCB or DDE and BMI in 5-y-old girls. For boys, no associations were observed.

Conclusions: Results suggest that prenatal exposure to PCB and DDE may play a role for subsequent obesity development. Girls whose mothers have a high prepregnancy BMI seem most affected.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Body Mass Index
  • Body Weight / drug effects
  • Child
  • Child, Preschool
  • Denmark
  • Dichlorodiphenyl Dichloroethylene / blood
  • Dichlorodiphenyl Dichloroethylene / toxicity*
  • Female
  • Humans
  • Linear Models
  • Male
  • Maternal Exposure
  • Milk, Human / chemistry
  • Obesity / chemically induced*
  • Overweight / blood
  • Overweight / metabolism
  • Polychlorinated Biphenyls / blood
  • Polychlorinated Biphenyls / toxicity*
  • Pregnancy
  • Prenatal Exposure Delayed Effects / chemically induced*
  • Prospective Studies
  • Waist Circumference / drug effects

Substances

  • Dichlorodiphenyl Dichloroethylene
  • Polychlorinated Biphenyls