Inflammation-induced cancer: crosstalk between tumours, immune cells and microorganisms

Nat Rev Cancer. 2013 Nov;13(11):759-71. doi: 10.1038/nrc3611.


Inflammation is a fundamental innate immune response to perturbed tissue homeostasis. Chronic inflammatory processes affect all stages of tumour development as well as therapy. In this Review, we outline the principal cellular and molecular pathways that coordinate the tumour-promoting and tumour-antagonizing effects of inflammation and we discuss the crosstalk between cancer development and inflammatory processes. In addition, we discuss the recently suggested role of commensal microorganisms in inflammation-induced cancer and we propose that understanding this microbial influence will be crucial for targeted therapy in modern cancer treatment.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Carcinogenesis
  • Cell Proliferation
  • Cell Transformation, Neoplastic / immunology
  • Gene Expression Regulation, Neoplastic*
  • Genome
  • Homeostasis
  • Humans
  • Immunity, Innate
  • Inflammation / complications*
  • Inflammation / immunology*
  • Inflammation / microbiology
  • Mice
  • Microbiota
  • Neoplasm Metastasis
  • Neoplasms / etiology*
  • Neoplasms / immunology*
  • Neoplasms / microbiology
  • Neoplasms / pathology*
  • Signal Transduction