Aerosol-assisted plasma deposition of hydrophobic polycations makes surfaces highly antimicrobial

Harris Liu; Yoojeong Kim; Kerrianne Mello; John Lovaasen; Apoorva Shah; Norman Rice; Jacqueline H Yim; Daphne Pappas; Alexander M Klibanov

doi:10.1007/s12010-013-0593-4

Aerosol-assisted plasma deposition of hydrophobic polycations makes surfaces highly antimicrobial

Appl Biochem Biotechnol. 2014 Feb;172(3):1254-64. doi: 10.1007/s12010-013-0593-4. Epub 2013 Oct 26.

Authors

Harris Liu¹, Yoojeong Kim, Kerrianne Mello, John Lovaasen, Apoorva Shah, Norman Rice, Jacqueline H Yim, Daphne Pappas, Alexander M Klibanov

Affiliation

¹ Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, 02139, USA.

PMID: 24158590
DOI: 10.1007/s12010-013-0593-4

Abstract

The currently used multistep chemical synthesis for making surfaces antimicrobial by attaching to them hydrophobic polycations is replaced herein by an aerosol-assisted plasma deposition procedure. To this end, N,N-hexyl,methyl-PEI (HMPEI) is directly plasma-coated onto a glass surface. The resultant immobilized HMPEI coating has been thoroughly characterized and shown to be robust, bactericidal against Escherichia coli, and virucidal against human influenza virus.

Publication types

Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Aerosols / chemical synthesis*
Aerosols / chemistry
Anti-Infective Agents / chemical synthesis
Anti-Infective Agents / chemistry*
Escherichia coli / drug effects
Glass / chemistry
Humans
Hydrophobic and Hydrophilic Interactions*
Polyamines / chemical synthesis
Polyamines / chemistry*
Polyelectrolytes
Polyethyleneimine / chemistry
Staphylococcus aureus / drug effects
Surface Properties / drug effects

Substances

Aerosols
Anti-Infective Agents
Polyamines
Polyelectrolytes
polycations
Polyethyleneimine